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Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group
Lee, Mijoon, Hesek, Dusan, Noll, Bruce C. and Mobashery, Shahriar Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group Chemical Papers, Vol.63, No. 5, 2009, 592-597
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Lee, Mijoon
Hesek, Dusan
Noll, Bruce C.
Mobashery, Shahriar
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| Title |
Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group
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| Journal name |
Chemical Papers
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| Publication date |
2009
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| Year available |
2009
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| Volume number |
63
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| Issue number |
5
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| ISSN |
0366-6352
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| Start page |
592
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| End page |
597
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2009
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| Language |
english
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| Subject |
270000 Biological Sciences
270100 Biochemistry and Cell Biology
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| Abstract/Summary |
Dimethylmaleoyl (DMM) moiety has become an important amine protective group in sugar chemistry. We disclose herein that DMM-containing D-glucosamine analogues, because of their electrophilic nature, are prone to reactions with strong nucleophiles, such as hydrazine, resulting in a set of undesired side products that are difficult to detect, yet proved to be problematic for organic synthesis.
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