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In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes
Mishra, Ajay K., Mishra, Shivani B. and Kaushik, Narender K. In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes Chemical Papers, Vol.63, No. 5, 2009, 543-547
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Mishra, Ajay K.
Mishra, Shivani B.
Kaushik, Narender K.
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| Title |
In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes
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| Journal name |
Chemical Papers
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| Publication date |
2009
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| Year available |
2009
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| Volume number |
63
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| Issue number |
5
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| ISSN |
0366-6352
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| Start page |
543
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| End page |
547
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2009
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| Language |
english
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| Subject |
270000 Biological Sciences
270100 Biochemistry and Cell Biology
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| Abstract/Summary |
Synthesis, characterization and biological studies of some thiodiamine metal complexes are described. Cobalt(II) and copper(II) complexes of type [Cu(L)2Cl2] and [Co(L)2SO4], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L1) and (cyclohexyl-N-thio)-1,3-propanediamine (L2), were synthesized. The synthesized copper and cobalt thiodiamine complexes were characterized by elemental analysis, IR, mass, UV-VIS and 1H NMR spectroscopic studies. Thiodiamines coordinate as a bidentate N-S ligand. The binding sites are azomethine nitrogen and thioamide sulfur. Molar conductance values in dimethylsulfoxide indicate non-electrolyte nature of the complexes. In vitro-antimicrobial screening shows promising results against both bacterial and fungal strains.
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