In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes

Mishra, Ajay K., Mishra, Shivani B. and Kaushik, Narender K. In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes Chemical Papers, Vol.63, No. 5, 2009, 543-547

Document type: ńĆl√°nok z ńćasopisu / Journal Article
Collection: Chemical papers  

Author(s) Mishra, Ajay K.
Mishra, Shivani B.
Kaushik, Narender K.
Title In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes
Journal name Chemical Papers
Publication date 2009
Year available 2009
Volume number 63
Issue number 5
ISSN 0366-6352
Start page 543
End page 547
Place of publication Poland
Publisher Versita
Collection year 2009
Language english
Subject 270000 Biological Sciences
270100 Biochemistry and Cell Biology
Abstract/Summary Synthesis, characterization and biological studies of some thiodiamine metal complexes are described. Cobalt(II) and copper(II) complexes of type [Cu(L)2Cl2] and [Co(L)2SO4], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L1) and (cyclohexyl-N-thio)-1,3-propanediamine (L2), were synthesized. The synthesized copper and cobalt thiodiamine complexes were characterized by elemental analysis, IR, mass, UV-VIS and 1H NMR spectroscopic studies. Thiodiamines coordinate as a bidentate N-S ligand. The binding sites are azomethine nitrogen and thioamide sulfur. Molar conductance values in dimethylsulfoxide indicate non-electrolyte nature of the complexes. In vitro-antimicrobial screening shows promising results against both bacterial and fungal strains.
 
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