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Application of isotachophoretic and conductometric methods for neomycin trisulphate determination
Kurzawa, Marzanna, Jastrzębska, Aneta and Szłyk, Edward Application of isotachophoretic and conductometric methods for neomycin trisulphate determination Chemical Papers, Vol.63, No. 3, 2009, 255-260
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Kurzawa, Marzanna
Jastrzębska, Aneta
Szłyk, Edward
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| Title |
Application of isotachophoretic and conductometric methods for neomycin trisulphate determination
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| Journal name |
Chemical Papers
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| Publication date |
2009
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| Year available |
2009
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| Volume number |
63
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| Issue number |
3
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| ISSN |
0366-6352
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| Start page |
255
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| End page |
260
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2009
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| Language |
english
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| Subject |
250000 Chemical Sciences
250200 Inorganic Chemistry
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| Abstract/Summary |
Determination of neomycin trisulphate (NMS) in a dosage form (Neox and Neosol) was carried out by capillary isotachophoresis (cITP) with conductometric detection. The following electrolytes: leading: 10 mmol dm−3 sodium acetate + 0.08 % hydroxyethylcelulose (HEC) and acetic acid to pH = 5.5, and terminating: 10 mmol dm−3 β-alanine were tested for isotachophoretic separation of NMS. The calibration curve was linear over the range of 10.00 mg dm−3 to 100.00 mg dm−3 with LOD = 5.69 mg dm−3 and LOQ = 18.96 mg dm−3. The results were compared to the conductometric determination of NMS with: ammonium molybdate (VI), silver nitrate (V) and Reinecke salt. Good accuracy was obtained from conductometric titration of NMS with Reinecke salt, the recoveries being as follows: 100 % (RSD = 1.99 %); 96.17 % (RSD = 2.10 %) and 95.22 % (RSD = 1.55 %) for NMS in pure form, Neosol and Neox, respectively.
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