1,3-Dibromo-5,5-dimethylhydantoin as a useful reagent for efficient synthesis of 3,4-dihydropyrimidin-2-(1 H )-ones under solvent-free conditions

Abdollahi-Alibeik, Mohammad and Zaghaghi, Zahra 1,3-Dibromo-5,5-dimethylhydantoin as a useful reagent for efficient synthesis of 3,4-dihydropyrimidin-2-(1 H )-ones under solvent-free conditions Chemical Papers, Vol.63, No. 1, 2009, 97-101

Document type: ńĆl√°nok z ńćasopisu / Journal Article
Collection: Chemical papers  

Author(s) Abdollahi-Alibeik, Mohammad
Zaghaghi, Zahra
Title 1,3-Dibromo-5,5-dimethylhydantoin as a useful reagent for efficient synthesis of 3,4-dihydropyrimidin-2-(1 H )-ones under solvent-free conditions
Journal name Chemical Papers
Publication date 2009
Year available 2009
Volume number 63
Issue number 1
ISSN 0366-6352
Start page 97
End page 101
Place of publication Poland
Publisher Versita
Collection year 2009
Language english
Subject 250000 Chemical Sciences
250200 Inorganic Chemistry
Abstract/Summary Efficient syntheses of 3,4-dihydropyrimidin-2-(1H)-ones and the corresponding thioxo derivatives using 1,3-dibromo-5,5-dimethylhydantoin (DBH) catalysis of a one-pot three-component Biginelli reaction of aldehydes, ethyl acetoacetate, and urea or thiourea under microwave irradiation are described. The advantages of this method are its short reaction times, high yields of the products, inexpensive and commercially available catalyst, and solvent-free conditions. Typical isolated yields exceed 70 % for arylaldehydes (9 examples) and aliphatic aldehydes (2 examples).
 
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