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Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions
Shevchenko, Ganna M. and Kulichenko, Sergey A. Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions Chemical Papers, Vol.62, No. 4, 2008, 435-439
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Shevchenko, Ganna M.
Kulichenko, Sergey A.
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| Title |
Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions
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| Journal name |
Chemical Papers
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| Publication date |
2008
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| Year available |
2008
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| Volume number |
62
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| Issue number |
4
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| ISSN |
0366-6352
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| Start page |
435
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| End page |
439
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2008
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| Language |
english
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| Subject |
250000 Chemical Sciences
250400 Analytical Chemistry
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| Abstract/Summary |
Protolytic properties of (+)-(S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (naproxen), 2-(3-benzoylphenyl)propionic acid (ketoprofen), 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid (furosemide), and N-(2,3-dimethylphenyl)anthranilic acid (mefenamic acid) in “oil-in-water” emulsions stabilized by surfactants were studied. The procedures for alkalimetric determination of naproxen, ketoprofen, furosemide, and mefenamic acid in emulsion media with indication of the equivalence point pH-metrically and with the use of indicators were proposed.
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