Synthesis and antimicrobial activity of quinoline-based 2-pyrazolines

Munawar, Munawar A., Azad, Muhammad, Athar, Makshoof and Groundwater, Paul W. Synthesis and antimicrobial activity of quinoline-based 2-pyrazolines Chemical Papers, Vol.62, No. 3, 2008, 288-293

Document type: ńĆl√°nok z ńćasopisu / Journal Article
Collection: Chemical papers  

Author(s) Munawar, Munawar A.
Azad, Muhammad
Athar, Makshoof
Groundwater, Paul W.
Title Synthesis and antimicrobial activity of quinoline-based 2-pyrazolines
Journal name Chemical Papers
Publication date 2008
Year available 2008
Volume number 62
Issue number 3
ISSN 0366-6352
Start page 288
End page 293
Place of publication Poland
Publisher Versita
Collection year 2008
Language english
Subject 270000 Biological Sciences
270100 Biochemistry and Cell Biology
Abstract/Summary A series of 2-pyrazolines was prepared in a reaction of quinolinylchalcones with phenyl hydrazine under both conventional and microwave-induced heating. Structures of the synthesized compounds were characterized by spectroscopic data and CHN analyses. All prepared compounds were tested for antimicrobial activity against bacterial strains, viz. Staphylococcus aureus, Salmonella typhii, Escherichia coli, and Shigella dysentery. Almost all synthesized compounds have shown antimicrobial activity; however, compounds with a chloro group as a substituent have been found to be more effective.
 
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