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Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites
Medvecký, Ľ., Štulajterová, R. and Briančin, J. Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites Chemical Papers, Vol.61, No. 6, 2007, 477-484
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Medvecký, Ľ.
Štulajterová, R.
Briančin, J.
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| Title |
Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites
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| Journal name |
Chemical Papers
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| Publication date |
2007
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| Year available |
2007
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| Volume number |
61
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| Issue number |
6
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| ISSN |
0366-6352
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| Start page |
477
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| End page |
484
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2007
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| Language |
english
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| Subject |
250000 Chemical Sciences
320000 Medical and Health Sciences
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| Abstract/Summary |
Porous calcium phosphate ceramics were prepared by sintering of mixtures of nanocrystalline apatitic calcium phosphate and fibrous natural cotton cellulose after pressing at temperatures of 1150 °C and 1250 °C. Micro-and macropores were present in microstructures of ceramic samples. The microstructures of porous ceramics were similar to those observed in bone tissues and fiber-like randomly oriented texture was observed in ceramics. Polyhydroxybutyrate (PHB) biopolymer layers are distributed homogeneously in the samples after evaporation of the diluent (chloroform) from the PHB vacuum impregnated porous samples. The tetracycline (TTC) release rate decreases with the content of polyhydroxybutyrate in the ceramic samples, which corresponds to the rise in amount of biopolymer displaced in the pores of ceramics. The concentration of TTC in the phosphate buffer saline solution varies almost linearly with time after the first seven hours from the start of the release of the calcium phosphate ceramic samples with 2.4 mass % of polyhydroxybutyrate. The initial burst effect was significantly depressed by the preparation method used.
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