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Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits
Pawłowska-Góral, K., Wardas, M., Wardas, P. and Rzepecka-Stojko, A. Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits Chemical Papers, Vol.61, No. 1, 2007, 6-10
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Pawłowska-Góral, K.
Wardas, M.
Wardas, P.
Rzepecka-Stojko, A.
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| Title |
Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits
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| Journal name |
Chemical Papers
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| Publication date |
2007
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| Year available |
2007
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| Volume number |
61
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| Issue number |
1
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| ISSN |
0366-6352
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| Start page |
6
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| End page |
10
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2007
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| Language |
english
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| Subject |
290000 Engineering and Technology
290100 Industrial Biotechnology and Food Sciences
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| Abstract/Summary |
The influence of CCl4 on the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), the value of the total antioxidant status (TAS), and the concentration of malonic dialdehyde (MDA) and glutathione (GSH) was monitored in plasma or whole blood of rabbits. The administration of CCl4 caused the increase of the SOD activity to approximately 150 % and the decrease in the activity of GPx and GR by about 50 %. These changes were accompanied with the increase in TAS value and MDA concentration and the decrease of GSH concentration. The effect of CCl4 was suppressed by the previous 7 days lasting or simultaneous administration of vitamin E. Oxidative stress caused by CCl4 was accompanied by the development of reactive oxygen forms, especially superoxide radical anion.
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