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Study of Local Anaesthetics, Part 156: Some Physicochemical and Lipophilic Properties of Pyrrolidinoethyl Esters of o-, m-, p-Alkoxy-Substituted Phenylcarbamic Acid
Gyurösiová, L., Sedlárová, E. and Čižmárik, J. Study of Local Anaesthetics, Part 156: Some Physicochemical and Lipophilic Properties of Pyrrolidinoethyl Esters of o-, m-, p-Alkoxy-Substituted Phenylcarbamic Acid Chemical Papers, Vol.56, No. 5, 2002, 340-344
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n565a340.pdf
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565a340.pdf |
application/pdf |
157.93KB |
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| Author(s) |
Gyurösiová, L.
Sedlárová, E.
Čižmárik, J.
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| Title |
Study of Local Anaesthetics, Part 156: Some Physicochemical and Lipophilic Properties of Pyrrolidinoethyl Esters of o-, m-, p-Alkoxy-Substituted Phenylcarbamic Acid
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| Journal name |
Chemical Papers
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| Publication date |
2002
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| Year available |
2002
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| Volume number |
56
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| Issue number |
5
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| ISSN |
0366-6352
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| Start page |
340
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| End page |
344
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2002
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| Language |
english
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| Subject |
320000 Medical and Health Sciences
320500 Pharmacology and Pharmaceutical Sciences
250000 Chemical Sciences
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| Abstract/Summary |
In the series of pyrrolidinoethyl esters of o-, m-, p-alkoxy-substituted phenylcarbamic acid the values of lipophilic parameters (RM, log Papp, log k) increase with lengthening of alkoxy chain on benzene ring, each methylene group increases the lipophilicity. Comparing advantages and disadvantages of different methods for a drug’s lipophilicity determination, as well as experiences from the laboratory, the easiest and best method seems to be HPLC. According to the results, the highest local anaesthetic activity can be assumed by the compounds with 6—8 carbon atoms in the side chain.
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