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Mass Spectrometric Study of Platinum Complexes Based on Cisplatin
Doležel, P. and Kubáň, V. Mass Spectrometric Study of Platinum Complexes Based on Cisplatin Chemical Papers, Vol.56, No. 4, 2002, 236-240
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n564a236.pdf
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564a236.pdf |
application/pdf |
194.26KB |
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| Author(s) |
Doležel, P.
Kubáň, V.
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| Title |
Mass Spectrometric Study of Platinum Complexes Based on Cisplatin
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| Journal name |
Chemical Papers
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| Publication date |
2002
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| Year available |
2002
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| Volume number |
56
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| Issue number |
4
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| ISSN |
0366-6352
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| Start page |
236
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| End page |
240
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2002
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| Language |
english
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| Subject |
250000 Chemical Sciences
270000 Biological Sciences
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| Abstract/Summary |
Flow injection-electrospray ionization-mass spectrometric and liquid chromatography-UV spectrometry- electrospray ionization-mass spectrometric systems with the possibility of collision-induced dissociation were used for characterization of Pt(II) and Pt(IV) complexes well known as antitumour agents. Mass spectra of cis-platin and trans-platin [PtII(NH3)2Cl2]0 under various experimental conditions were compared. Ion clusters and adduct ions with the assumed structure are described. The process of partial ion fragmentation allows characterization of the LA12 product, [PtIV(C10H17N)(NH3)(CH3COO)2Cl2]0, a new agent with enhanced cancerostatic activity. The structure of the principal impurity, [PtIV(C10H17N)(NH3)(CH3COO)Cl3]0, present in the final product of the LA12 synthesis, was designed after chromatographic separation and subsequent mass spectra analysis.
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