Quantitative MALDI-TOFMS Analysis of Amino Acids Applying Soft Modeling Methods

Maršálek, P., Farková, M. and Havel, J. Quantitative MALDI-TOFMS Analysis of Amino Acids Applying Soft Modeling Methods Chemical Papers, Vol.56, No. 3, 2002, 188-193

Document type: Článok z časopisu / Journal Article
Collection: Chemical papers  
 
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Author(s) Maršálek, P.
Farková, M.
Havel, J.
Title Quantitative MALDI-TOFMS Analysis of Amino Acids Applying Soft Modeling Methods
Journal name Chemical Papers
Publication date 2002
Year available 2002
Volume number 56
Issue number 3
ISSN 0366-6352
Start page 188
End page 193
Place of publication Poland
Publisher Versita
Collection year 2002
Language english
Subject 250000 Chemical Sciences
250400 Analytical Chemistry
Abstract/Summary This study demonstrates the applicability of Matrix-Assisted Laser Desorption/Ionization Timeof- Flight Mass Spectrometry (MALDI-TOFMS) in multicomponent analysis of amino acids with various chemometric methods like experimental design, partial least squares (PLS), and artificial neural networks (ANN). Several negative factors influencing reproducibility of intensities were systematically studied and their influence was eliminated. Binary mixtures of L-alanine and L-isoleucine were analyzed and evaluated using PLS and ANN. The results obtained show the possibility to use MALDI-TOFMS in quantitative analysis of amino acids.
 
 
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