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Quantitative MALDI-TOFMS Analysis of Amino Acids Applying Soft Modeling Methods
Maršálek, P., Farková, M. and Havel, J. Quantitative MALDI-TOFMS Analysis of Amino Acids Applying Soft Modeling Methods Chemical Papers, Vol.56, No. 3, 2002, 188-193
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n563a188.pdf
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563a188.pdf |
application/pdf |
249.73KB |
0 |
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| Author(s) |
Maršálek, P.
Farková, M.
Havel, J.
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| Title |
Quantitative MALDI-TOFMS Analysis of Amino Acids Applying Soft Modeling Methods
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| Journal name |
Chemical Papers
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| Publication date |
2002
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| Year available |
2002
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| Volume number |
56
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| Issue number |
3
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| ISSN |
0366-6352
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| Start page |
188
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| End page |
193
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2002
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| Language |
english
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| Subject |
250000 Chemical Sciences
250400 Analytical Chemistry
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| Abstract/Summary |
This study demonstrates the applicability of Matrix-Assisted Laser Desorption/Ionization Timeof- Flight Mass Spectrometry (MALDI-TOFMS) in multicomponent analysis of amino acids with various chemometric methods like experimental design, partial least squares (PLS), and artificial neural networks (ANN). Several negative factors influencing reproducibility of intensities were systematically studied and their influence was eliminated. Binary mixtures of L-alanine and L-isoleucine were analyzed and evaluated using PLS and ANN. The results obtained show the possibility to use MALDI-TOFMS in quantitative analysis of amino acids.
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