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Enzymatic transformation of flavonoids
Viskupičová, Jana, Šturdík, Ernest and Ondrejovič, Miroslav Enzymatic transformation of flavonoids Acta Chimica Slovaca, Vol.2, No. 1, 2009, 88-106
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
acs_0039.pdf
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acs_0039.pdf |
application/pdf |
272.59KB |
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| Author(s) |
Viskupičová, Jana
Šturdík, Ernest
Ondrejovič, Miroslav
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| Title |
Enzymatic transformation of flavonoids
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| Journal name |
Acta Chimica Slovaca
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| Publication date |
2009
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| Year available |
2009
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| Volume number |
2
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| Issue number |
1
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| ISSN |
1337-978X
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| Start page |
88
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| End page |
106
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| Total pages |
19
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| Place of publication |
Bratislava
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| Publisher |
Slovak Technical University
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| Collection year |
2009
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| Language |
english
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| Subject |
270000 Biological Sciences
270100 Biochemistry and Cell Biology
270800 Biotechnology
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| Abstract/Summary |
There is a growing interest in natural pharmacologically active compounds with either healthprotecting or therapeutic properties to be used in medicine, pharmaceutical, cosmetic or food industry. Flavonoids are excellent candidates for this role due to their potent beneficial biological activities. However, many of dietary flavonoids are glycosylated, and therefore their use in certain fields is limited, especially due to their low solubility in lipophilic systems. An effective method of resolving this disadvantage has been introduced, i.e. enzyme-mediated acylation of sugar moieties of flavonoid glycosides with either aliphatic or aromatic molecules. Moreover, specific modifications of a flavonoid skeleton may confer several beneficial characteristics to the parental molecule. Additionally, it can be interesting to increase natural flavonoid diversity and produce potentially bioactive derivatives by enzymatic conversion. This review summarizes to-date knowledge on flavonoid biotransformations. The key factors affecting enzyme-mediated acylation of flavonoids, such as the type and origin of the biocatalyst, the structure and concentration of the substrates (acyl donor, acyl acceptor and their ratio), the reaction media, and the reaction temperature, are being discussed relating to the reaction rate and the performance of the biocatalytic process.
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| Keyword(s) |
flavonoid transformation
enzymes
acyl donor and acceptor
reaction media
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