Optical Resolution of Ethyl 2-(Benzylamino)-4-oxo-4-phenylbutanoate with Tartaric Acid A Practical Synthesis of D-Homophenylalanine

Berkeš, D., Lopuch, J., Proksa, B. and Považanec, F. Optical Resolution of Ethyl 2-(Benzylamino)-4-oxo-4-phenylbutanoate with Tartaric Acid A Practical Synthesis of D-Homophenylalanine Chemical Papers, Vol.57, No. 5, 2003, 350-354

Document type: Článok z časopisu / Journal Article
Collection: Chemical papers  
 
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Author(s) Berkeš, D.
Lopuch, J.
Proksa, B.
Považanec, F.
Title Optical Resolution of Ethyl 2-(Benzylamino)-4-oxo-4-phenylbutanoate with Tartaric Acid A Practical Synthesis of D-Homophenylalanine
Journal name Chemical Papers
Publication date 2003
Year available 2003
Volume number 57
Issue number 5
ISSN 0366-6352
Start page 350
End page 354
Place of publication Poland
Publisher Versita
Collection year 2003
Language english
Subject 250000 Chemical Sciences
250300 Organic Chemistry
Abstract/Summary The resolution of ethyl (±)-2-(benzylamino)-4-oxo-4-phenylbutanoate with L-tartaric acid, followed by catalytic hydrogenation represents a practical and convenient three-step synthesis of Dhomophenylalanine starting from commercial ethyl benzoylacrylate. Capillary zone electrophoresis in the presence of cyclodextrins was used to determine the ee of the L-tartrate.
 
 
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