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A spectrofluorimetric method for the determination of acitretin in pharmaceuticals
Feng, Suling, Zhang, Yi and Fan, Jing A spectrofluorimetric method for the determination of acitretin in pharmaceuticals Chemical Papers, Vol.63, No. 4, 2009, 484-488
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Feng, Suling
Zhang, Yi
Fan, Jing
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| Title |
A spectrofluorimetric method for the determination of acitretin in pharmaceuticals
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| Journal name |
Chemical Papers
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| Publication date |
2009
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| Year available |
2009
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| Volume number |
63
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| Issue number |
4
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| ISSN |
0366-6352
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| Start page |
484
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| End page |
488
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2009
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| Language |
english
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| Subject |
250000 Chemical Sciences
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| Abstract/Summary |
A simple, rapid, and highly sensitive spectrofluorimetric method for the determination of acitretin was developed based on the strong green fluorescence of acitretin. Influence of organic solvents on the fluorescence spectra of acitretin was studied. Effects of pH, standing time, and foreign ions on the determination of acitretin were also examined. Under the optimum conditions, linear relationship between the relative fluorescence intensity and the concentration of acitretin in the range of 30.0–1100 ng mL−1 was obtained. Detection limit of this method is 9.56 ng mL−1 for acitretin. Relative standard deviation for the determination of 480 ng mL−1 of acitretin was 1.70 %. This method was used for the determination of acitretin in pharmaceuticals and the results were compared with those obtained by the HPLC method.
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