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Synthesis, characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide
Qu, Jian-Qiang, Qu, Ling, Yang, Qiu-Hua and Wang, Liu-Fang Synthesis, characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide Chemical Papers, Vol.63, No. 4, 2009, 426-431
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Qu, Jian-Qiang
Qu, Ling
Yang, Qiu-Hua
Wang, Liu-Fang
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| Title |
Synthesis, characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide
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| Journal name |
Chemical Papers
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| Publication date |
2009
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| Year available |
2009
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| Volume number |
63
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| Issue number |
4
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| ISSN |
0366-6352
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| Start page |
426
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| End page |
431
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2009
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| Language |
english
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| Subject |
250000 Chemical Sciences
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| Abstract/Summary |
Four transition metal(II) complexes with podophyllic acid hydrazide (HL) were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR, and 1H NMR. The complexes have the general formula ML2 · nH2O, where M = Zn, Cu, Co, and Ni, n = 2 or 0. Anti-tumor activities of podophyllotoxin, HL, ZnL2 · 2H2O, and NiL2 were tested by both the MTT and the SRB method. The results show that the activities of the complexes against the tumor cells tested are superior to HL and the anti-tumor activity of NiL2 is even similar to that of podophyllotoxin.
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