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Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares
Bordbar, Maryam, Yeganeh-Faal, Ali, Ghasemi, Jahanbakhsh, Ahari-Mostafavi, Mohammad Mahdi, Sarlak, Nahid and Baharifard, Mohammad Taghi Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares Chemical Papers, Vol.63, No. 3, 2009, 336-344
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Bordbar, Maryam
Yeganeh-Faal, Ali
Ghasemi, Jahanbakhsh
Ahari-Mostafavi, Mohammad Mahdi
Sarlak, Nahid
Baharifard, Mohammad Taghi
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| Title |
Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares
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| Journal name |
Chemical Papers
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| Publication date |
2009
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| Year available |
2009
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| Volume number |
63
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| Issue number |
3
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| ISSN |
0366-6352
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| Start page |
336
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| End page |
344
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2009
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
A simple, sensitive and selective spectrophotometric method for simultaneous determination of tretinoin and minoxidil using partial least square (PLS) calibration and H-point standard addition method (HPSAM) is described. The results of the H-point standard addition method show that minoxidil and tretinoin can be determined simultaneously with the concentration ratio of tretinoin to minoxidil varying from 2: 1 to 1: 33 in mixed samples. A partial least squares multivariate calibration method for the analysis of binary mixtures of tretinoin and minoxidil was also developed. The total relative standard error for applying the PLS method to eleven synthetic samples in the concentration range of 0–10 μg mL−1 tretinoin and 0–32 μg mL−1 minoxidil was 2.59 %. Both proposed methods (PLS and HPSAM) were also successfully applied in the determination of tretinoin and minoxidil in several synthetic pharmaceutical solutions.
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