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Preparation of trisodium O-monoalkyl and O-monoaryl diphosphates
Gregáň, Fridrich, Melicherčík, Milan, Gregáň, Juraj and Remko, Milan Preparation of trisodium O-monoalkyl and O-monoaryl diphosphates Chemical Papers, Vol.62, No. 2, 2008, 223-226
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Gregáň, Fridrich
Melicherčík, Milan
Gregáň, Juraj
Remko, Milan
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| Title |
Preparation of trisodium O-monoalkyl and O-monoaryl diphosphates
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| Journal name |
Chemical Papers
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| Publication date |
2008
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| Year available |
2008
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| Volume number |
62
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| Issue number |
2
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| ISSN |
0366-6352
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| Start page |
223
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| End page |
226
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2008
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
Trisodium O-methyl, O-butyl, O-phenyl, and O-(4-nitrophenyl) diphosphates were synthesized from sodium dimethylamido-O-(2-cyanoethyl) phosphate and O-alkyl-and O-aryl phosphoric acids. While in the previously described method, sodium hydroxide was used for the preparation of O-phenyl diphosphate, in our current work, we present an improved protocol, where sodium methoxide is used to increase the yields of O-alkyl and O-aryl diphosphates. The structures of final compounds were determined by 1H NMR, 31P NMR, and IR spectroscopy. The sodium O-alkyl- and O-aryl diphosphate salts prepared by this method may be used for the study of biological activity of diphosphate analogues.
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