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Synthesis and biological activity of new 1,3,4-thiadiazole derivatives
Aly, A. A. and El-Sayed, R. Synthesis and biological activity of new 1,3,4-thiadiazole derivatives Chemical Papers, Vol.60, No. 1, 2006, 56-60
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Author(s) |
Aly, A. A.
El-Sayed, R.
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| Title |
Synthesis and biological activity of new 1,3,4-thiadiazole derivatives
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| Journal name |
Chemical Papers
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| Publication date |
2006
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| Year available |
2006
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| Volume number |
60
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| Issue number |
1
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| ISSN |
0366-6352
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| Start page |
56
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| End page |
60
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2006
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
The aminothiadiazole (II) on treatment with aromatic aldehydes yielded Schiff bases, which cyclized to thiazolidinone derivatives by reaction with thioglycolic acid. Reaction of II with phenyl isocyanate and phenyl isothiocyanate afforded the carbamide and carbothiamide derivatives, respectively, which on reaction with malonic acid in acetyl chloride gave barbituric and thiobarbituric acid derivatives. However, reaction of carbon disulfide and methyl iodide with II gave dithiocarbamidate derivative which on treatment with ethylenediamine or o-phenylenediamine gave the condensed N-imidazolylthiadiazolylamine derivatives.
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