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Optical Resolution of Ethyl 2-(Benzylamino)-4-oxo-4-phenylbutanoate with Tartaric Acid A Practical Synthesis of D-Homophenylalanine
Berkeš, D., Lopuch, J., Proksa, B. and Považanec, F. Optical Resolution of Ethyl 2-(Benzylamino)-4-oxo-4-phenylbutanoate with Tartaric Acid A Practical Synthesis of D-Homophenylalanine Chemical Papers, Vol.57, No. 5, 2003, 350-354
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n575a350.pdf
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575a350.pdf |
application/pdf |
146.67KB |
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| Author(s) |
Berkeš, D.
Lopuch, J.
Proksa, B.
Považanec, F.
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| Title |
Optical Resolution of Ethyl 2-(Benzylamino)-4-oxo-4-phenylbutanoate with Tartaric Acid A Practical Synthesis of D-Homophenylalanine
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| Journal name |
Chemical Papers
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| Publication date |
2003
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| Year available |
2003
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| Volume number |
57
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| Issue number |
5
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| ISSN |
0366-6352
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| Start page |
350
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| End page |
354
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2003
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
The resolution of ethyl (±)-2-(benzylamino)-4-oxo-4-phenylbutanoate with L-tartaric acid, followed by catalytic hydrogenation represents a practical and convenient three-step synthesis of Dhomophenylalanine starting from commercial ethyl benzoylacrylate. Capillary zone electrophoresis in the presence of cyclodextrins was used to determine the ee of the L-tartrate.
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