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4-Substituted Aryl Bromides Coupling with 4-Methoxybenzene-1-thiol by Means of Copper Catalysts
Jampílek, J., Doležal, M., Kuneš, J., Raich, I. and Liška, F. 4-Substituted Aryl Bromides Coupling with 4-Methoxybenzene-1-thiol by Means of Copper Catalysts Chemical Papers, Vol.59, No. 3, 2005, 182-186
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n593a182.pdf
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593a182.pdf |
application/pdf |
136.98KB |
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| Author(s) |
Jampílek, J.
Doležal, M.
Kuneš, J.
Raich, I.
Liška, F.
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| Title |
4-Substituted Aryl Bromides Coupling with 4-Methoxybenzene-1-thiol by Means of Copper Catalysts
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| Journal name |
Chemical Papers
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| Publication date |
2005
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| Year available |
2005
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| Volume number |
59
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| Issue number |
3
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| ISSN |
0366-6352
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| Start page |
182
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| End page |
186
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2005
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
Synthesis of diaryl sulfides via nucleophilic coupling of the 4-substituted aryl bromides with 4- methoxybenzene-1-thiol is described. A radical-ionic mechanism of this coupling, carried out in the presence of heterogeneous copper catalysts, has been proposed. The reactivity of aryl bromides is correlated to the calculated values of electronic deficiency in position C-4 of the aromatic ring. The prepared compounds should be used as the leading building blocks of quinlukast higher homologues.
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