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Synthesis and Antimicrobial Activity of New
Sukdolak, S., Solujić, S., Manojlović, N. and Krstić, Lj. Synthesis and Antimicrobial Activity of New Chemical Papers, Vol.59, No. 1, 2005, 37-40
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n591a37.pdf
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591a37.pdf |
application/pdf |
138.95KB |
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| Author(s) |
Sukdolak, S.
Solujić, S.
Manojlović, N.
Krstić, Lj.
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| Title |
Synthesis and Antimicrobial Activity of New
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| Journal name |
Chemical Papers
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| Publication date |
2005
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| Year available |
2005
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| Volume number |
59
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| Issue number |
1
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| ISSN |
0366-6352
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| Start page |
37
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| End page |
40
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2005
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
New N-[4-(4-hydroxy-2-oxo-2H-chromen-3-yl)thiazol-2-yl]benzenesulfonamides were synthesized and their antimicrobial activity was tested in relation to some bacteria and fungi. Through the reaction of bromination with phenyltrimethylammonium tribromide, 3-acetyl-4-hydroxy-2H-chromen- 2-one yields 3-bromoacetyl-4-hydroxy-2H-chromen-2-one which through reaction with thiourea gives 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one (III) in the form of a bromide salt. Compound III was the starting substrate in condensation reactions with corresponding arenesulfonyl chlorides yielding the required derivatives. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR, 1H and 13C NMR). Also, the disk diffusion method was used to test the inhibitory activity of four of the new sulfonamides in relation to twelve microorganisms.
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