Synthesis and Antimicrobial Activity of New

Sukdolak, S., Solujić, S., Manojlović, N. and Krstić, Lj. Synthesis and Antimicrobial Activity of New Chemical Papers, Vol.59, No. 1, 2005, 37-40

Document type: Článok z časopisu / Journal Article
Collection: Chemical papers  
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Author(s) Sukdolak, S.
Solujić, S.
Manojlović, N.
Krstić, Lj.
Title Synthesis and Antimicrobial Activity of New
Journal name Chemical Papers
Publication date 2005
Year available 2005
Volume number 59
Issue number 1
ISSN 0366-6352
Start page 37
End page 40
Place of publication Poland
Publisher Versita
Collection year 2005
Language english
Subject 250000 Chemical Sciences
250300 Organic Chemistry
Abstract/Summary New N-[4-(4-hydroxy-2-oxo-2H-chromen-3-yl)thiazol-2-yl]benzenesulfonamides were synthesized and their antimicrobial activity was tested in relation to some bacteria and fungi. Through the reaction of bromination with phenyltrimethylammonium tribromide, 3-acetyl-4-hydroxy-2H-chromen- 2-one yields 3-bromoacetyl-4-hydroxy-2H-chromen-2-one which through reaction with thiourea gives 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one (III) in the form of a bromide salt. Compound III was the starting substrate in condensation reactions with corresponding arenesulfonyl chlorides yielding the required derivatives. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR, 1H and 13C NMR). Also, the disk diffusion method was used to test the inhibitory activity of four of the new sulfonamides in relation to twelve microorganisms.
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