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A New Stereocontrolled Approach to a Key Intermediate in the Synthesis of (2S,3R)-Capreomycidine
Martinková, M., Gonda, J. and Džoganová, M. A New Stereocontrolled Approach to a Key Intermediate in the Synthesis of (2S,3R)-Capreomycidine Chemical Papers, Vol.58, No. 4, 2004, 292-293
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n584a292.pdf
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584a292.pdf |
application/pdf |
91.51KB |
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| Author(s) |
Martinková, M.
Gonda, J.
Džoganová, M.
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| Title |
A New Stereocontrolled Approach to a Key Intermediate in the Synthesis of (2S,3R)-Capreomycidine
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| Journal name |
Chemical Papers
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| Publication date |
2004
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| Year available |
2004
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| Volume number |
58
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| Issue number |
4
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| ISSN |
0366-6352
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| Start page |
292
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| End page |
293
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2004
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| Language |
english
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| Abstract/Summary |
A new synthetic approach to the key intermediate in the stereoselective synthesis of (2S,3R)- capreomycidine was developed. The synthesis is based on novel domino reaction combining (3,3)-sigmatropic rearrangement of chiral allylic thiocyanate derived from D-methionine and intramolecular amino addition to arising isothiocyanate to produce diastereomerically (4R,5R)-4- vinyltetrahydro-1H-imidazole-2-thione derivative.
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