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Synthesis and Biological Evaluation of Some New Fused Heterobicyclic Derivatives Containing 1,2,4-Triazolo/1,2,4-Triazinopyridinone Moieties
Abdel-Monem, W. R. Synthesis and Biological Evaluation of Some New Fused Heterobicyclic Derivatives Containing 1,2,4-Triazolo/1,2,4-Triazinopyridinone Moieties Chemical Papers, Vol.58, No. 4, 2004, 276-285
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n584a276.pdf
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584a276.pdf |
application/pdf |
250.87KB |
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| Author(s) |
Abdel-Monem, W. R.
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| Title |
Synthesis and Biological Evaluation of Some New Fused Heterobicyclic Derivatives Containing 1,2,4-Triazolo/1,2,4-Triazinopyridinone Moieties
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| Journal name |
Chemical Papers
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| Publication date |
2004
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| Year available |
2004
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| Volume number |
58
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| Issue number |
4
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| ISSN |
0366-6352
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| Start page |
276
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| End page |
285
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2004
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
Syntheses of fused heterobicyclic systems containing 1,2,4-triazolo/1,2,4-triazinopyridinone moieties were accomplished by heterocyclization of 4-(4-chlorophenyl)-1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (III ) or 6-amino-4-(4-chlorophenyl)-2-oxo-1-(5,6-diphenyl-1,2,4-triazin-3-ylamino)-1,2-dihydropyridine-3,5-dicarbonitrile (XII) with α,β-bifunctional oxygen and halooxo compounds in different media in order to establish a relation between structure and their activities. Compounds III and XII which contain 1,2-biamino group are more favoured to the ringclosure reactions. Structure assignments of new products have been established on the basis of elemental analysis and spectral data. The antimicrobial activity of the products has been also evaluated where some compounds showed a better activity against selected tested microbes in comparison with control.
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