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Voltammetric Determination of Labetalol in Pharmaceuticals and Spiked Human Urine
Radi, A., El-Sherif, Z. and Wassel, A. Voltammetric Determination of Labetalol in Pharmaceuticals and Spiked Human Urine Chemical Papers, Vol.58, No. 4, 2004, 242-246
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n584a242.pdf
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584a242.pdf |
application/pdf |
174.79KB |
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| Author(s) |
Radi, A.
El-Sherif, Z.
Wassel, A.
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| Title |
Voltammetric Determination of Labetalol in Pharmaceuticals and Spiked Human Urine
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| Journal name |
Chemical Papers
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| Publication date |
2004
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| Year available |
2004
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| Volume number |
58
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| Issue number |
4
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| ISSN |
0366-6352
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| Start page |
242
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| End page |
246
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2004
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| Language |
english
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| Subject |
250000 Chemical Sciences
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| Abstract/Summary |
The electrochemical oxidation of labetalol was investigated by cyclic, linear sweep and differential pulse voltammetry at carbon paste electrode in Britton—Robinson buffers over the pH range 2.0—10.0. For analytical purposes, a well-defined adsorption-controlled anodic peak was obtained in Britton—Robinson buffer at pH 2.0. By anodic adsorptive linear sweep and differential pulse voltammetry, linear calibration plots were obtained in the ranges of 2.5 × 10−6—1.0 × 10−5 mol dm−3 and 2.5×10−8—1.0 × 10−5 mol dm−3 for both techniques, respectively. Detection limits were found 1.0 × 10−6 mol dm−3 for LSV and 1.0 × 10−8 mol dm−3 for DPV. Based on this study, two simple, rapid, selective, and sensitive voltammetric methods were developed for the determination of labetalol in tablet dosage form. The preconcentration/medium exchange/voltammetry approach was applied for the drug determination in spiked human urine.
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