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An Immunomodulating Pectic Arabinogalactan from Roots of Cistanche deserticola
Ebringerová, A., Hromádková, Z., Hříbalová, V. and Hirsch, J. An Immunomodulating Pectic Arabinogalactan from Roots of Cistanche deserticola Chemical Papers, Vol.56, No. 5, 2002, 320-325
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n565a320.pdf
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565a320.pdf |
application/pdf |
182.07KB |
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| Author(s) |
Ebringerová, A.
Hromádková, Z.
Hříbalová, V.
Hirsch, J.
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| Title |
An Immunomodulating Pectic Arabinogalactan from Roots of Cistanche deserticola
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| Journal name |
Chemical Papers
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| Publication date |
2002
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| Year available |
2002
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| Volume number |
56
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| Issue number |
5
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| ISSN |
0366-6352
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| Start page |
320
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| End page |
325
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2002
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| Language |
english
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| Subject |
290000 Engineering and Technology
290600 Chemical Engineering
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| Abstract/Summary |
The crude cold water-extractable polysaccharide isolated from the holoparasite Cistanche deserticola Y. C. Ma. was separated into several fractions by cetavlon precipitation and ion-exchange chromatography. The immunological properties of the fractions were characterized using mitogenic and comitogenic rat thymocytes tests. The most potent fraction after purification by gel filtration yielded the polysaccharide cistan A. It was composed of L-arabinose, D-galactose, L-rhamnose, and D-galacturonic acid in the mole ratio 6.3:10.0:1.0:0.8, in addition to minute amounts of Dxylose and D-glucose. The relative mean molecular mass was 201 × 103. The results of chemical and spectroscopic investigations indicated the cistan A to comprise a complex of pectic arabino- 3,6-galactan type II with lowly-branched 3,5-α-L-arabinan. The polysaccharide exhibits remarkable immunomodulatory activities exceeding those of the commercial immunomodulator Zymosan.
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