Antimycobacterial 1-Aryl-5-benzylsulfanyltetrazoles

Weisser, K., Adamec, J., KuneŇ°, J. and Kaustov√°, J. Antimycobacterial 1-Aryl-5-benzylsulfanyltetrazoles Chemical Papers, Vol.58, No. 3, 2004, 214-219

Document type: ńĆl√°nok z ńćasopisu / Journal Article
Collection: Chemical papers  
 
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Author(s) Weisser, K.
Adamec, J.
KuneŇ°, J.
Kaustov√°, J.
Title Antimycobacterial 1-Aryl-5-benzylsulfanyltetrazoles
Journal name Chemical Papers
Publication date 2004
Year available 2004
Volume number 58
Issue number 3
ISSN 0366-6352
Start page 214
End page 219
Place of publication Poland
Publisher Versita
Collection year 2004
Language english
Subject 250000 Chemical Sciences
250300 Organic Chemistry
Abstract/Summary A group of twenty-two 1-Aryl-5-benzylsulfanyltetrazoles and 5-alkylsulfanyl-1-aryltetrazoles was synthesized, and was evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. To describe the structure-antimycobacterial activity relationships the Hansch approach was used. Optimal values of logarithm of partition coefficients were 4.1-4.4 with the exception of M. avium. Benzylsulfanyl derivatives were more active than alkylsulfanyl derivatives.
 
 
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