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Antimycobacterial 1-Aryl-5-benzylsulfanyltetrazoles
Weisser, K., Adamec, J., Kuneš, J. and Kaustová, J. Antimycobacterial 1-Aryl-5-benzylsulfanyltetrazoles Chemical Papers, Vol.58, No. 3, 2004, 214-219
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Document type:
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Článok z časopisu / Journal Article |
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Collection:
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Chemical papers
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| Attached Files |
| Name |
Description |
MIMEType |
Size |
Downloads |
n583a214.pdf
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583a214.pdf |
application/pdf |
430.41KB |
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| Author(s) |
Weisser, K.
Adamec, J.
Kuneš, J.
Kaustová, J.
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| Title |
Antimycobacterial 1-Aryl-5-benzylsulfanyltetrazoles
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| Journal name |
Chemical Papers
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| Publication date |
2004
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| Year available |
2004
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| Volume number |
58
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| Issue number |
3
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| ISSN |
0366-6352
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| Start page |
214
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| End page |
219
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| Place of publication |
Poland
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| Publisher |
Versita
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| Collection year |
2004
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| Language |
english
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| Subject |
250000 Chemical Sciences
250300 Organic Chemistry
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| Abstract/Summary |
A group of twenty-two 1-Aryl-5-benzylsulfanyltetrazoles and 5-alkylsulfanyl-1-aryltetrazoles was synthesized, and was evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. To describe the structure-antimycobacterial activity relationships the Hansch approach was used. Optimal values of logarithm of partition coefficients were 4.1-4.4 with the exception of M. avium. Benzylsulfanyl derivatives were more active than alkylsulfanyl derivatives.
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